Substances starting with D
Every substance in the newest version of the EU reference dates list that starts with D, with how often a PSUR is due. Open one for its data lock points and submission dates.
236 substances
- dabigatranevery 3 years
- dabrafenibevery 3 years
- dacarbazineevery 5 years
- dacomitinibevery 3 years
- dactinomycinevery 9 years
- dalbavancinevery 3 years
- dalteparin sodiumevery 2 years
- damoctocog alfa pegolevery 2 years
- danaparoidevery 5 years
- danazolevery 9 years
- danicopanevery 1 year
- dantroleneevery 9 years
- dantrolene sodium hemiheptahydrateevery 1 year
- dapagliflozin, dapagliflozin / metformin, saxagliptin / dapagliflozin, dapagliflozin / sitagliptinevery 3 years
- dapiprazoleevery 9 years
- dapoxetineevery 5 years
- dapsone, dapsone / ferrous oxalateevery 8 years
- daptomycinevery 5 years
- daratumumabevery 2 years
- darbepoetin alfaevery 3 years
- daridorexantevery 1 year
- darifenacinevery 5 years
- darolutamideevery 1 year
- darunavirevery 5 years
- darunavir / cobicistatevery 3 years
- darunavir / cobicistat / emtricitabine / tenofovir alafenamideevery 3 years
- dasatinibevery 3 years
- datopotamab deruxtecanevery 6 months
- daunorubicinevery 3 years
- daunorubicin / cytarabineevery 3 years
- deanol and all combinations with deanol except for diclofenac deanolevery 9 years
- decitabineevery 5 years
- decitabine / cedazuridineevery 1 year
- defatted powder of Arachis hypogaea L., semen (peanuts)every 3 years
- deferasiroxevery 5 years
- deferiproneevery 5 years
- deferoxamineevery 9 years
- defibrotideevery 3 years
- deflazacortevery 9 years
- degarelixevery 5 years
- dehydrocholic acidevery 9 years
- delafloxacinevery 2 years
- delamanidevery 1 year
- delapril / manidipine, delapril / indapamideevery 5 years
- delgocitinibevery 2 years
- delorazepamevery 9 years
- demeclocyclineevery 10 years
- demeclocycline / triamcinoloneevery 13 years
- dengue tetravalent vaccine (live, attenuated)every 1 year
- denosumab (indicated for osteoporosis and for bone loss associated with hormone ablation in prostate cancer)every 3 years
- denosumab (indicated for skeletal related events associated with bone metastases and for giant cell tumour of bone)every 3 years
- deoxycholic acidevery 3 years
- depemokimabevery 6 months
- deproteinised hemoderivative of calf blood, deproteinised hemoderivative of calf blood / macrogol 400every 8 years
- dequalinium, dequalinium / cinchocaine, dequalinium / lidocaine, dequalinium / enoxolone / tyrothricin/ hydrocortisone / lidocaineevery 11 years
- dermatan sulfateevery 7 years
- desfluraneevery 3 years
- desloratadineevery 5 years
- desloratadine / pseudoephedrineevery 5 years
- desmopressinevery 3 years
- desogestrelevery 5 years
- desogestrel / ethinylestradiolevery 5 years
- desonideevery 9 years
- desoximetasoneevery 10 years
- deucravacitinibevery 1 year
- deutetrabenazineevery 1 year
- deutivacaftor / tezacaftor / vanzacaftorevery 6 months
- dexamethasone (apart from centrally authorised products - topical use)every 5 years
- dexamethasone (centrally authorised product indicated in uveitis and macular oedema)every 5 years
- dexamethasone (systemic use)every 5 years
- dexamethasone / diphenhydramine hydrochlorideevery 9 years
- dexamethasone / framycetin / gramicidinevery 11 years
- dexamethasone / framycetin sulfate / polymyxin b sulfateevery 10 years
- dexamethasone / gentamicin / tetryzolineevery 9 years
- dexamethasone / heparin sodiumevery 11 years
- dexamethasone / lidocaineevery 8 years
- dexamethasone / neomycin / polymyxin b, dexamethasone / neomycinevery 10 years
- dexamethasone / netilmicinevery 5 years
- dexamethasone / polymyxin b / trimethoprimevery 12 years
- dexamethasone / tobramycin (topical and ophtalmic use, except systemic formulations)every 5 years
- dexamethasone isonicotinate / tramazoline hydrochloride monohydrateevery 11 years
- dexamethasone sodium phosphate / gentamicin sulfateevery 9 years
- dexamfetamineevery 3 years
- dexchlorpheniramineevery 3 years
- dexibuprofenevery 3 years
- dexketoprofen, dexketoprofen / tramadolevery 5 years
- dexlansoprazole, lansoprazoleevery 5 years
- dexmedetomidineevery 3 years
- dexpanthenolevery 10 years
- dexpanthenol / dimethyl sulfoxide / heparinevery 8 years
- dexpanthenol / heparinevery 9 years
- dexpanthenol / hydrocortisoneevery 9 years
- dexpanthenol / polyvinyl alcoholevery 9 years
- dexpanthenol / retinol palmitateevery 20 years
- dexpanthenol / xylometazolineevery 8 years
- dexrazoxaneevery 3 years
- dextranevery 10 years
- dextran 40 / sodium chloride / potassium chloride / magnesium sulphate heptahydrate / disodium phosphate dodecahydrate / monopotassium phosphate / dextrose monohydrateevery 10 years
- dextran 70 / sodium chlorideevery 11 years
- dextromethorphan / doxylamine / ephedrine / paracetamolevery 9 years
- dextromethorphan / doxylamine / paracetamolevery 9 years
- dextromethorphan / doxylamine / paracetamol / pseudoephedrineevery 9 years
- dextromethorphan / paracetamol / phenylephrineevery 10 years
- dextromethorphan hydrobromide / diphenhydramine hydrochloride / levomentholevery 7 years
- dextromethorphan hydrobromide / paracetamol / phenylpropanolamine hydrochlorideevery 9 years
- dextromethorphan hydrobromide / paracetamol / promethazine hydrochlorideevery 7 years
- dextromethorphan hydrobromide / pseudoephedrine hydrochloride / triprolidine hydrochlorideevery 10 years
- dextromethorphan, dextromethorphan / guaifenesinevery 5 years
- diacereinevery 5 years
- diamorphineevery 7 years
- diazepamevery 8 years
- diazepam / nortriptyline hydrochlorideevery 10 years
- diazepam / pyridoxineevery 11 years
- diazoxideevery 9 years
- dibotermin alfaevery 5 years
- dibrompropamidine , propamidineevery 11 years
- dichloralphenazone / isometheptene mucate / paracetamolevery 9 years
- diclofenac (systemic formulations)every 5 years
- diclofenac (topical formulations), diclofenac / heparinevery 6 years
- diclofenac / lidocaineevery 5 years
- diclofenac / misoprostolevery 3 years
- diclofenac / omeprazoleevery 5 years
- diclofenac / pyridoxine / thiamineevery 9 years
- diclofenac sodium / orphenadrine citrateevery 8 years
- dicloxacillinevery 10 years
- dicycloverine, dicyloverine/ paracetamol, dicycloverine/ doxylamineevery 11 years
- didecyldimethylammonium chlorideevery 9 years
- dienogestevery 5 years
- dienogest / estradiol (contraception indication)every 5 years
- dienogest / estradiol (HRT indication)every 5 years
- dienogest / ethinylestradiolevery 5 years
- dienogest / ethinylestradiol (prolonged-release tablet)every 1 year
- diethylamine salicylateevery 11 years
- diethylamine salicylate / myrtecaineevery 10 years
- diethylamine-salicylate / escinevery 8 years
- diethylcarbamazineevery 9 years
- difelikefalinevery 2 years
- diflucortoloneevery 9 years
- diflucortolone valerate / chlorquinaldolevery 13 years
- diflucortolone valerate / isoconazole nitrateevery 9 years
- diflucortolone valerate / salicylic acidevery 13 years
- diflunisal (for centrally authorised products)every 3 years
- diflunisal (for nationally authorised products)every 9 years
- digitoxinevery 10 years
- digoxin specific antibody fragmentsevery 9 years
- digoxin, metildigoxinevery 10 years
- dihydrocodeineevery 11 years
- dihydroergocristine / piracetamevery 9 years
- dihydroergotamineevery 3 years
- dihydrotachysterolevery 10 years
- dihydroxyaluminum sodium carbonate, dihydroxyaluminum sodium carbonate / dimeticoneevery 10 years
- diiodohydroxyquinolineevery 9 years
- diisopropylamineevery 9 years
- diltiazemevery 5 years
- dimercaptosuccinic acid (dmsa)every 9 years
- dimethyl fumarate (psoriasis)every 3 years
- dimethyl fumarate, diroximel fumarate (multiple sclerosis)every 3 years
- dimeticoneevery 10 years
- dimeticone / guaiazuleneevery 8 years
- dimeticone / metoclopramide / oxazepam hemisuccinate / polyenzymesevery 10 years
- dimetindeneevery 10 years
- dimetindene / phenylephrineevery 5 years
- dinoprost trometamolevery 9 years
- dinoprostoneevery 3 years
- dinutuximab betaevery 1 year
- diosmectiteevery 9 years
- diosminevery 9 years
- diosmin / hesperidin, ascorbic acid/ dry Ruscus extract titrated in sterolic heterosides/ Hesperidin methyl chalconeevery 9 years
- diphenhydramine / guaifenesin / levomentholevery 9 years
- diphenhydramine / paracetamolevery 7 years
- diphenhydramine hydrochloride / lorazepamevery 9 years
- diphenhydramine hydrochloride / paracetamol / pseudoephedrine hydrochlorideevery 9 years
- diphenhydramine, ammonium chloride / diphenhydramine hydrochloride, diphenhydramine hydrochloride / levomenthol, ammonium chloride / diphenhydramine hydrochloride / levomentholevery 10 years
- diphtheria / tetanus / pertussis (acellular, component) / hepatitis B (rDNA) / poliomyelitis (inactivated) / haemophilus type b conjugate vaccine (adsorbed)every 3 years
- diphtheria / tetanus / pertussis (acellular, component) / poliomyelitis (inactivated) / haemophilus type b conjugate vaccine (adsorbed)every 3 years
- diphtheria / tetanus / pertussis (acellular, component) and poliomyelitis (inactivated) vaccine (adsorbed), diphtheria / tetanus / pertussis (acellular, component) and poliomyelitis (inactivated) vaccine (adsorbed, reduced antigen(s) content)every 5 years
- diphtheria / tetanus / pertussis (acellular, component) vaccine (adsorbed), diphtheria / tetanus / pertussis (acellular, component) vaccine (adsorbed) reduced antigens contentsevery 5 years
- diphtheria / tetanus / pertussis antigens (pertussis toxoid, filamentous haemagglutinin, pertactin) (acellular, component) / hepatitis b (rdna) / poliomyelitis (inactivated) / haemophilus type b conjugate vaccines (adsorbed)every 3 years
- diphtheria / tetanus / pertussis antigens (pertussis toxoid, filamentous haemagglutinin) (acellular, component) / hepatitis b (rdna) / poliomyelitis (inactivated) / haemophilus type b conjugate vaccines (adsorbed)every 3 years
- diphtheria / tetanus / poliomyelitis (inactivated) vaccine (adsorbed, reduced antigens(s) content)every 5 years
- diphtheria / tetanus vaccines (adsorbed), diphtheria vaccines (adsorbed)every 5 years
- diprophylline, diprophylline / turpentine oilevery 11 years
- dipyridamoleevery 9 years
- disodium edetate dihydrate / sodium dihydrogen phosphate dihydrate / sodium hydrogen phosphate dodecahydrate / water for injectionevery 9 years
- disodium hydrogen phosphate / sodium dihydrogen phosphate, phosphate sodiumevery 13 years
- disodium phosphate anhydrous / sodium hydrogen carbonate / trometamolevery 9 years
- disopyramideevery 9 years
- distigmineevery 9 years
- disulfiramevery 9 years
- dobesilate calciumevery 9 years
- dobutamineevery 3 years
- docetaxelevery 5 years
- docosanolevery 5 years
- docusate, docusate/sorbitolevery 10 years
- dolutegravir / rilpivirineevery 3 years
- dolutegravir, dolutegravir / abacavir / lamivudine, dolutegravir / lamivudineevery 3 years
- domperidoneevery 5 years
- donanemabevery 6 months
- donepezilevery 5 years
- donepezil / memantineevery 5 years
- donidalorsenevery 6 months
- dopamineevery 9 years
- dopamine hydrochlorideevery 6 months
- dopexamineevery 9 years
- doravirineevery 5 years
- doravirine / lamivudine / tenofovir disoproxilevery 5 years
- dornase alfaevery 5 years
- dorocubicel / allogeneic umbilical cord-derived CD34- cells, non-expandedevery 6 months
- dorzolamideevery 5 years
- dorzolamide / timololevery 5 years
- dostarlimabevery 1 year
- dosulepinevery 9 years
- doxapram hydrochlorideevery 10 years
- doxazosinevery 7 years
- doxecitine / doxribtimineevery 6 months
- doxepinevery 9 years
- doxorubicinevery 5 years
- doxycyclineevery 8 years
- doxylamineevery 5 years
- doxylamine succinate / pyridoxine hydrochlorideevery 10 years
- dronabinol/cannabidiolevery 5 years
- dronedaroneevery 5 years
- droperidolevery 9 years
- droperidol / fentanylevery 10 years
- drospirenoneevery 3 years
- drospirenone / estetrolevery 1 year
- drospirenone / estradiolevery 5 years
- drospirenone / ethinylestradiolevery 5 years
- drotaverineevery 9 years
- dulaglutideevery 3 years
- duloxetineevery 5 years
- dupilumabevery 1 year
- durvalumabevery 1 year
- dutasteride, dutasteride / tamsulosineevery 5 years
- dydrogesteroneevery 9 years
- dydrogesterone / estradiolevery 7 years
Source: European Medicines Agency, list of EU reference dates and frequency of submission of periodic safety update reports, EMA/630645/2012 Rev.165, published 21 Oct 2026.