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Look up a substance

The EU reference dates list says how often a periodic safety update report is due for each active substance, and from which data lock point. Search it by substance, including the salt form you happen to have to hand.

Try an active substance: amlodipine, metoprolol succinate, amoxicillin / clavulanic acid.

Source: European Medicines Agency, list of EU reference dates and frequency of submission of periodic safety update reports, EMA/630645/2012 Rev.164, published 23 Sept 2026.