Substances starting with M
Every substance in the newest version of the EU reference dates list that starts with M, with how often a PSUR is due. Open one for its data lock points and submission dates.
167 substances
- macimorelinevery 5 years
- macitentanevery 3 years
- macitentan / tadalafilevery 1 year
- macrogol 3350, macrogol 3350 combinations (oral use)every 5 years
- macrogol 4000, macrogol 4000 combinations (oral use)every 5 years
- magaldrateevery 8 years
- magnesium / pyridoxineevery 13 years
- magnesium aspartate / potassium aspartateevery 8 years
- magnesium chlorideevery 20 years
- magnesium gluconateevery 9 years
- magnesium hydroxideevery 5 years
- magnesium orotate, magnesium lactateevery 8 years
- magnesium pidolateevery 15 years
- magnesium sulfateevery 5 years
- magnesium sulfate / sodium sulfate / potassium sulfateevery 3 years
- magnesium sulfate heptahydrate, potassium chloride, xylitol, procaine hydrochlorideevery 3 years
- malathionevery 18 years
- manidipineevery 5 years
- mannitol (all indications apart from cystic fibrosis)every 5 years
- mannitol (indicated in cystic fibrosis)every 3 years
- maprotilineevery 9 years
- maralixibatevery 6 months
- maravirocevery 5 years
- maribavirevery 1 year
- marstacimabevery 1 year
- mavacamtenevery 1 year
- mavorixaforevery 6 months
- measles / mumps / rubella / varicella vaccines (live)every 3 years
- measles / mumps / rubella vaccines (live, attenuated)every 3 years
- mebendazoleevery 15 years
- mebeverineevery 9 years
- mecaserminevery 1 year
- mecillinamevery 9 years
- meclozineevery 15 years
- meclozine hydrochloride / pyridoxine hydrochlorideevery 10 years
- mecobalaminevery 10 years
- medazepamevery 9 years
- medrogestoneevery 8 years
- medroxyprogesteroneevery 5 years
- mefenamic acidevery 9 years
- mefloquineevery 5 years
- mefruside / nifedipineevery 9 years
- megestrolevery 9 years
- meglumine antimonateevery 11 years
- melatoninevery 3 years
- meldoniumevery 8 years
- meloxicamevery 5 years
- melperoneevery 9 years
- melphalan, melphalan flufenamideevery 3 years
- memantineevery 5 years
- meningococcal group a, c, w135, y conjugate vaccine (conjugated to Corynebacterium diphtheriae CRM197 protein)every 5 years
- meningococcal group a, c, w135, y conjugate vaccine (conjugated to tetanus toxoid carrier protein)every 3 years
- meningococcal group B vaccine (recombinant, adsorbed)every 3 years
- meningococcal group c polysaccharide conjugate vaccineevery 3 years
- meningococcal group-B vaccine (rDNA, component, adsorbed)every 3 years
- menotrophinevery 7 years
- mepartricinevery 10 years
- mephenoxaloneevery 8 years
- mepivacaine hydrochloride / polyestradiol phosphateevery 11 years
- mepolizumabevery 3 years
- meptazinolevery 9 years
- mepyramineevery 9 years
- mepyramine / phenylephrineevery 9 years
- mercaptamine (Indicated for the treatment of corneal cystine crystal deposit only)every 3 years
- mercaptamine (treatment of nephropathic cystinosis)every 5 years
- mercaptopurineevery 3 years
- meropenemevery 3 years
- meropenem / vaborbactamevery 3 years
- mesalazineevery 2 years
- mesnaevery 8 years
- mesoglycanevery 9 years
- mesteroloneevery 5 years
- metacyclineevery 10 years
- metadoxineevery 9 years
- metamizoleevery 3 years
- metamizole sodium / pitofenone hydrochlorideevery 7 years
- metamizole sodium / triacetonamine tosilateevery 5 years
- metaraminolevery 3 years
- metergolineevery 5 years
- metforminevery 3 years
- methacholineevery 5 years
- methadoneevery 5 years
- methandienoneevery 8 years
- methenamineevery 11 years
- methocarbamol, methocarbamol / paracetamolevery 10 years
- methohexitalevery 5 years
- methotrexateevery 5 years
- methoxsalenevery 10 years
- methoxy polyethylene glycol-epoetin betaevery 3 years
- methoxyfluraneevery 3 years
- methyl salicylate, menthol / methyl salicylate, menthol / methyl salicylate / camphor,methyl salicylate/ camphor, methyl salicylate / menthol / camphor / tocopherol, methyl salicylate / camphor / menthol / turpentine (essence, oil), methyl salicylate / menthol / camphor / hydroxyethyl salicylate, methyl salicylate / menthol / camphor / hydroxyethyl salicylate / benzyl nicotinateevery 5 years
- methylaminolevulinateevery 5 years
- methyldopaevery 9 years
- methylergometrineevery 9 years
- methylnaltrexone bromideevery 3 years
- methylphenidateevery 5 years
- methylphenobarbitalevery 5 years
- methylprednisolone (systemic use)every 3 years
- methylprednisolone (topical use)every 5 years
- methylthioninium / naphazolineevery 10 years
- methylthioninium chlorideevery 3 years
- metoclopramideevery 5 years
- metolazoneevery 8 years
- metoprololevery 8 years
- metreleptinevery 1 year
- metronidazoleevery 9 years
- metronidazole / miconazole, chlorquinaldol / metronidazoleevery 8 years
- metronidazole / neomycin / nystatinevery 5 years
- metronidazole / spiramycinevery 10 years
- metylphenobarbital / phenytoin sodiumevery 10 years
- metyraponeevery 6 years
- mexazolamevery 7 years
- mexiletine (centrally authorised products only)every 3 years
- mexiletine (nationally authorised products only)every 9 years
- mianserinevery 9 years
- micafunginevery 5 years
- miconazole, hydrocortisone / miconazole nitrate, miconazole nitrate / zinc oxide, benzoyl peroxide / miconazoleevery 10 years
- midazolam (all pharmaceutical forms and indications apart from oromucosal and nasal routes of administration)every 5 years
- midazolam (oromucosal solution or nasal routes of administration)every 3 years
- midecamycinevery 9 years
- midodrineevery 10 years
- midostaurinevery 5 years
- mifamurtideevery 5 years
- mifepristoneevery 3 years
- mifepristone / misoprostolevery 3 years
- migalastatevery 3 years
- miglustat (all other indications)every 5 years
- miglustat (for treatment of Pompe disease)every 1 year
- milnacipranevery 3 years
- milrinoneevery 3 years
- minocyclineevery 5 years
- minoxidil (non topical formulations)every 3 years
- minoxidil (topical formulation)every 3 years
- mirabegronevery 3 years
- mirdametinibevery 6 months
- mirikizumabevery 1 year
- mirtazapineevery 5 years
- mirvetuximab soravtansineevery 1 year
- misoprostol (gastrointestinal indication)every 3 years
- misoprostol (gynaecological indication - labour induction)every 3 years
- misoprostol (gynaecological indication - termination of pregnancy)every 3 years
- mitapivatevery 1 year
- mitomycinevery 9 years
- mitotaneevery 5 years
- mitoxantroneevery 3 years
- mivacuriumevery 10 years
- mizolastineevery 5 years
- moclobemideevery 5 years
- modafinilevery 3 years
- mogamulizumabevery 3 years
- molsidomineevery 9 years
- momelotinibevery 1 year
- mometasoneevery 5 years
- mometasone furoate/olopatadineevery 3 years
- montelukastevery 3 years
- morniflumateevery 8 years
- moroctocog alfaevery 5 years
- morphine, morphine / cyclizineevery 5 years
- mosunetuzumabevery 6 months
- moxifloxacin (systemic use)every 4 years
- moxifloxacin (topical ophthalmic use)every 5 years
- moxonidineevery 5 years
- mucopolysaccharide polysulfuric acid ester (chondroitin), mucopolysaccharide polysulfuric acid ester (chondroitin)/ glucosamine [oral and intramuscular use]every 9 years
- mucopolysaccharide polysulfuric acid ester (chondroitin), mucopolysaccharide polysulfuric acid ester (chondroitin)/salicylic acid, mucopolysaccharide polysulfuric acid ester (chondroitin)/salicylic acid/flufenamic acid, mucopolysaccharide polysulfuric acid ester (chondroitin)/salicylic acid/suprarenal extract [cutaneous use]every 9 years
- mupirocinevery 5 years
- mycophenolate mofetil, mycophenolic acidevery 3 years
- myristalkonium, benzalkonium (vaginal use only)every 13 years
Source: European Medicines Agency, list of EU reference dates and frequency of submission of periodic safety update reports, EMA/630645/2012 Rev.165, published 21 Oct 2026.