Substances starting with E
Every substance in the newest version of the EU reference dates list that starts with E, with how often a PSUR is due. Open one for its data lock points and submission dates.
173 substances
- ebastineevery 5 years
- econazole, econazole nitrate / triamcinolone acetonideevery 5 years
- eculizumabevery 2 years
- edotreotideevery 3 years
- edoxabanevery 3 years
- efanesoctocog alfaevery 1 year
- efavirenzevery 5 years
- efavirenz / emtricitabine / tenofovirevery 5 years
- efbemalenograstim alfaevery 1 year
- efgartigimod alfaevery 1 year
- efinaconazoleevery 5 years
- eflornithine (topical use)every 5 years
- efmoroctocog alfaevery 1 year
- eftrenonacog alfaevery 3 years
- elacestrantevery 6 months
- eladocagene exuparvovecevery 1 year
- elafibranorevery 6 months
- elbasvir / grazoprevirevery 5 years
- eletriptanevery 5 years
- eliglustatevery 3 years
- elinzanetantevery 6 months
- elosulfase alfaevery 3 years
- elotuzumabevery 3 years
- elranatamabevery 6 months
- eltrombopagevery 3 years
- emedastineevery 3 years
- emicizumabevery 3 years
- empagliflozin / linagliptinevery 3 years
- empagliflozin, empagliflozin / metforminevery 2 years
- emtricitabineevery 3 years
- emtricitabine / rilpivirine / tenofovir alafenamideevery 3 years
- emtricitabine / rilpivirine / tenofovir disoproxilevery 3 years
- emtricitabine / tenofovir alafenamideevery 3 years
- emtricitabine / tenofovir disoproxilevery 3 years
- enalaprilevery 5 years
- enalapril / hydrochlorothiazideevery 5 years
- enalapril / nitrendipineevery 7 years
- enalapril maleate (centrally authorised product for use in children below the age of 18)every 1 year
- enalapril maleate / felodipineevery 9 years
- enalapril maleate / lercanidipineevery 7 years
- encorafenibevery 3 years
- enfortumab vedotinevery 1 year
- enfuvirtideevery 5 years
- enoxaparinevery 3 years
- enoximoneevery 9 years
- enoxoloneevery 9 years
- ensitrelvirevery 6 months
- entacaponeevery 3 years
- entecavirevery 5 years
- enterococcus faeciumevery 10 years
- entrectinibevery 6 months
- enzalutamideevery 3 years
- eosineevery 8 years
- epcoritamabevery 6 months
- ephedrineevery 10 years
- ephedrine hydrochloride / glaucine hydrobromideevery 9 years
- epinastineevery 5 years
- epinephrine (except for nasal use)every 5 years
- epinephrine (for nasal use)every 6 months
- epinephrine / lidocaineevery 8 years
- epinephrine / mepivacaine hydrochloride, mepivacaine / norepinephrine, mepivacaineevery 7 years
- epirubicinevery 5 years
- eplerenoneevery 7 years
- eplontersenevery 6 months
- epoetin alfaevery 3 years
- epoetin betaevery 3 years
- epoetin thetaevery 5 years
- epoetin zetaevery 3 years
- epoprostenolevery 5 years
- eprosartanevery 5 years
- eprosartan / hydrochlorothiazideevery 5 years
- eptacog alfaevery 8 years
- eptacog beta (activated)every 2 years
- eptifibatideevery 3 years
- eptinezumabevery 3 years
- eravacyclineevery 3 years
- erbiumevery 5 years
- erdafitinibevery 1 year
- erdosteineevery 10 years
- erenumabevery 3 years
- ergometrine / oxytocinevery 10 years
- eribulinevery 5 years
- erlotinibevery 3 years
- ertapenemevery 5 years
- ertugliflozin / metformin, ertugliflozin / sitagliptin, ertugliflozinevery 3 years
- erysimumevery 8 years
- erythromycin (systemic use)every 3 years
- erythromycin (topical use)every 5 years
- erythromycin / tretinoin, isotretinoin, erythromycin / isotretinoinevery 5 years
- erythromycin / zinc acetateevery 9 years
- escherichia coli (living cells)every 15 years
- escherichia coli lysateevery 5 years
- escinevery 9 years
- escitalopramevery 5 years
- esculoside / phenylephrineevery 9 years
- esketamine (except for centrally authorised products)every 5 years
- esketamine (for centrally authorised product only)every 3 years
- eslicarbazepine acetateevery 3 years
- esmololevery 9 years
- esomeprazoleevery 5 years
- esomeprazole / naproxenevery 5 years
- estazolamevery 9 years
- estetrolevery 6 months
- estradiol (17-beta) / progesteroneevery 7 years
- estradiol (except cream/balm/emulsion for application in female genital area)every 5 years
- estradiol / estriolevery 9 years
- estradiol / estriol / levonorgestrelevery 9 years
- estradiol / levonorgestrelevery 8 years
- estradiol / nomegestrol acetateevery 5 years
- estradiol / norethisteroneevery 5 years
- estradiol / prasterone enantateevery 10 years
- estradiol / testosteroneevery 10 years
- estradiol benzoate / prednisolone / salicylic acidevery 8 years
- estradiol valerate / norgestrelevery 8 years
- estradiol, estradiol /prednisolone (only cream/balm/emulsion for application in the female genital area)every 3 years
- estramustineevery 10 years
- estriolevery 15 years
- estriol / lactobacillus acidophilusevery 8 years
- estrogen / medroxyprogesteroneevery 5 years
- etacrynic acidevery 11 years
- etamsylateevery 15 years
- etanerceptevery 5 years
- etelcalcetideevery 3 years
- ethacridineevery 9 years
- ethambutolevery 9 years
- ethanol (cutaneous route of administration)every 16 years
- ethanol / orthophenylphenolevery 10 years
- ethanol / povidone iodinated, povidone iodinated / isopropyl alcohol (covers other synonymous terms such as 2-propanol)every 9 years
- ethanol extracts of: Iberis amara L., planta tota recens / Angelica archangelica L., radix / Matricaria recutita L., flos / Carum carvi L., fructus / Silybum marianum (L.) Gaertn., fructus / Melissa officinalis L., folium / Mentha piperita L., folium / Chelidonium majus L., herba / Glycyrrhiza glabra L., radixevery 3 years
- ethanolamineevery 8 years
- ethinylestradiolevery 8 years
- ethinylestradiol / etonogestrelevery 5 years
- ethinylestradiol / gestodeneevery 5 years
- ethinylestradiol / levonorgestrelevery 5 years
- ethinylestradiol / norelgestrominevery 5 years
- ethinylestradiol / norethisteroneevery 5 years
- ethinylestradiol / norgestimateevery 5 years
- ethosuximideevery 3 years
- ethyl esters of iodised fatty acids from poppyseed oilevery 15 years
- ethyl loflazepateevery 8 years
- ethyl nicotinate / hydroxyethyl salicylate / nonylic acid vanillylamideevery 9 years
- ethylmorphineevery 11 years
- etidronateevery 5 years
- etifoxineevery 3 years
- etilefrine (except for treatment of priapism)every 12 years
- etodolacevery 8 years
- etofenamateevery 9 years
- etofylline, etofylline / theophyllineevery 8 years
- etomidateevery 5 years
- etonogestrelevery 3 years
- etoposideevery 5 years
- etoricoxibevery 5 years
- etranacogene dezaparvovecevery 6 months
- etrasimodevery 1 year
- etravirineevery 3 years
- etuvetidigene autotemcelevery 6 months
- eucalyptus / paracetamol / tenoate sodiumevery 11 years
- eucalyptus oilevery 13 years
- eugenolevery 9 years
- euphrasia officinalis / calendula officinalis / magnesium carbonicumevery 18 years
- everolimus (indicated for advanced renal cell carcinoma, advanced breast cancer, advanced neuroendocrine tumors (gastrointestinal, lung, pancreatic cancers) (NET)every 5 years
- everolimus (indicated for astrocytoma (SEGA), renal angiomyolipoma, refractory seizures)every 5 years
- everolimus (indicated for rejection of transplanted organs)every 3 years
- evinacumabevery 3 years
- evolocumabevery 3 years
- ex vivo expanded autologous human corneal epithelial cells containing stem cellsevery 1 year
- exagamglogene autotemcelevery 6 months
- exemestaneevery 5 years
- exenatideevery 3 years
- ezetimibeevery 5 years
- ezetimibe / pitavastatinevery 5 years
- ezetimibe / rosuvastatinevery 3 years
- ezetimibe / simvastatinevery 5 years
Source: European Medicines Agency, list of EU reference dates and frequency of submission of periodic safety update reports, EMA/630645/2012 Rev.165, published 21 Oct 2026.