Substances starting with I
Every substance in the newest version of the EU reference dates list that starts with I, with how often a PSUR is due. Open one for its data lock points and submission dates.
129 substances
- ibandronic acidevery 5 years
- iberidis amarae herba recens / matricariae flos / menthae piperitae folium / melissae folium / glycyrrhizae radix / carvi fructusevery 18 years
- ibrutinibevery 3 years
- ibuprofen (indicated in ductus arteriosus)every 3 years
- ibuprofen / levomentholevery 8 years
- ibuprofen / paracetamolevery 8 years
- ibuprofen / phenylephrineevery 8 years
- ibuprofen / pseudoephedrineevery 3 years
- ibuprofen, ibuprofen lysine (not indicated in ductus arteriosus), ibuprofen / caffeineevery 3 years
- ibutilideevery 5 years
- icatibantevery 3 years
- ichthammolevery 16 years
- ichthammol / titanium dioxide / zinc oxide and other substances, zinc oxide/dimethiconeevery 13 years
- icosapent ethylevery 3 years
- icotrokinraevery 6 months
- idarubicinevery 3 years
- idarucizumabevery 3 years
- idebenone (centrally authorised products)every 3 years
- idecabtagene vicleucelevery 1 year
- idelalisibevery 5 years
- idursulfaseevery 3 years
- ifosfamideevery 8 years
- iloprost (intravenous (IV)use only)every 5 years
- iloprost (nebuliser solution only)every 5 years
- imatinibevery 3 years
- imetelstatevery 6 months
- imidaprilevery 7 years
- imigluceraseevery 3 years
- imipenem / cilastatin / relebactamevery 3 years
- imipramineevery 8 years
- imiquimodevery 5 years
- imlifidaseevery 6 months
- imlunestrantevery 6 months
- immunocyanineevery 15 years
- inactivated leptospire vaccineevery 5 years
- inavolisibevery 6 months
- inclisiranevery 3 years
- indacaterolevery 5 years
- indacaterol / glycopyrronium / mometasoneevery 1 year
- indacaterol / glycopyrronium bromideevery 5 years
- indacaterol / mometasone furoateevery 1 year
- indapamideevery 7 years
- indapamide / perindopril, indapamide / ramiprilevery 5 years
- indigo carmineevery 13 years
- indium (111In) chloride, indium (111In) oxineevery 8 years
- indium (111In) pentetateevery 8 years
- indium (111In) pentetreotideevery 8 years
- indobufenevery 8 years
- indocyanine greenevery 7 years
- indometacinevery 3 years
- inebilizumabevery 1 year
- infliximabevery 3 years
- influenza mRNA vaccine / COVID-19 mRNA vaccine (mCombriax)every 6 months
- influenza vaccine (live, nasal)every 1 year
- influenza vaccine (recombinant, prepared in cell culture)every 1 year
- influenza vaccine (split virion, inactivated) (non centrally authorised products)every 1 year
- influenza vaccine (surface antigen, inactivated, adjuvanted, prepared in cell cultures)every 6 months
- influenza vaccine (surface antigen, inactivated, adjuvanted)every 1 year
- influenza vaccine (surface antigen, inactivated, prepared in cell cultures)every 1 year
- influenza vaccine (surface antigen, inactivated)every 1 year
- inosine pranobexevery 5 years
- inotersenevery 2 years
- inotuzumab ozogamicinevery 3 years
- insulin aspartevery 3 years
- insulin degludec, insulin degludec / insulin aspartevery 3 years
- insulin detemirevery 5 years
- insulin efsitora alfaevery 6 months
- insulin glargineevery 3 years
- insulin glargine / lixisenatideevery 3 years
- insulin glulisineevery 3 years
- insulin human (Intraperitoneal use only)every 3 years
- insulin human, insulin human / insulin isophane (subcutaneous and intravenous routes of administration)every 5 years
- Insulin icodecevery 1 year
- insulin icodec / semaglutideevery 6 months
- insulin lisproevery 3 years
- interferon beta-1a (intramuscular use)every 5 years
- interferon beta-1a (subcutaneous use)every 5 years
- interferon beta-1bevery 5 years
- interferon gammaevery 8 years
- iobitridolevery 5 years
- iodine (123i) iobenguaneevery 8 years
- iodine (131i) iobenguaneevery 5 years
- iodixanolevery 8 years
- ioflupane (123i)every 5 years
- iohexolevery 8 years
- iomeprolevery 8 years
- iopamidolevery 8 years
- iopromideevery 8 years
- ioversolevery 8 years
- ioxitalamateevery 8 years
- ipidacrineevery 8 years
- ipilimumabevery 3 years
- ipratropiumevery 6 years
- ipratropium / salbutamolevery 3 years
- ipratropium / xylometazolineevery 6 years
- iptacopanevery 6 months
- irbesartan, irbesartan / hydrochlorothiazideevery 5 years
- irinotecan (except for liposomal formulations)every 5 years
- irinotecan (liposomal formulations)every 3 years
- iron / oral preparationsevery 10 years
- iron dextranevery 3 years
- iron in any combination with multivitamins and/or minerals and/or aminoacids (except for combinations with folic acid)every 13 years
- iron in combination with folic acid and/or multivitamins and/or minerals and/or aminoacidsevery 13 years
- iron sucrose (parenteral use)every 3 years
- isatuximabevery 2 years
- isavuconazoleevery 3 years
- isocarboxazidevery 11 years
- isoconazoleevery 9 years
- isofluraneevery 3 years
- isoniazid, isoniazid / pyridoxine hydrochloride, isoniazid / rifampicin, isoniazid / pyrazinamide / rifampicin, ethambutol / isoniazid / pyrazinamide / rifampicinevery 5 years
- isoprenalineevery 13 years
- isopropyl alcohol , isopropyl alcohol (covers other synonymous terms such as 2-propanol) / benzalkoniumevery 10 years
- isopropyl alcohol (covers other synonymous terms such as 2-propanol) / propyl alcohol / mecetronium ethyl sulfateevery 5 years
- isopropyl myristate / liquid paraffinevery 9 years
- isosorbideevery 13 years
- isothipendylevery 10 years
- isotretinoin (oral formulations)every 1 year
- ispaghula husk, ispaghula husk / ispaghula seed, ispaghula husk / ispaghula seed / senna Tinnervelly pod, psyllium, psyllium husk, psyllium seedevery 10 years
- isradipineevery 15 years
- itoprideevery 5 years
- itraconazoleevery 5 years
- ivabradineevery 3 years
- ivacaftorevery 3 years
- ivacaftor / tezacaftor / elexacaftorevery 1 year
- ivermectin (systemic use)every 3 years
- ivermectin (topical use)every 3 years
- ivosidenibevery 1 year
- ixazomibevery 3 years
- ixekizumabevery 3 years
Source: European Medicines Agency, list of EU reference dates and frequency of submission of periodic safety update reports, EMA/630645/2012 Rev.165, published 21 Oct 2026.