Substances starting with L
Every substance in the newest version of the EU reference dates list that starts with L, with how often a PSUR is due. Open one for its data lock points and submission dates.
134 substances
- l-lysine hydrochloride / l-arginine hydrochlorideevery 3 years
- l(+)biaspartate / glutamic acid / glycin / magnesium / potassium / pyridoxineevery 10 years
- labetalolevery 8 years
- lacidipineevery 5 years
- lacosamideevery 3 years
- lactic acidevery 18 years
- lactic acid / salicylic acidevery 9 years
- lactic acid / urea, ureaevery 10 years
- lactic acid/oxalic acid / nitric acid / cupric nitrate/ acetic acidevery 10 years
- lactitolevery 5 years
- lactobacillus all subspecies and combinations of subspecies (intramuscular use)every 5 years
- lactobacillus all subspecies and combinations of subspecies (oral and vaginal use)every 10 years
- lactose monohydrate / lactuloseevery 18 years
- lactuloseevery 5 years
- lactulose / paraffin liquid / vaselineevery 18 years
- lamivudine (chronic hepatitis B)every 5 years
- lamivudine (HIV infections), lamivudine / zidovudineevery 5 years
- lamotrigineevery 5 years
- lanadelumabevery 3 years
- landiololevery 5 years
- lanreotideevery 3 years
- lanthanumevery 3 years
- lapatinibevery 5 years
- laronidaseevery 3 years
- larotrectinibevery 6 months
- lasmiditanevery 1 year
- latanoprostevery 5 years
- latanoprost (eye drop emulsions containing CKC)every 1 year
- latanoprost / netarsudilevery 3 years
- latanoprost / timololevery 5 years
- lauromacrogol 400every 18 years
- lauromacrogol 400 / ureaevery 8 years
- lauromacrogols combinationsevery 18 years
- lavender oilevery 5 years
- lazertinibevery 6 months
- lebrikizumabevery 1 year
- lecanemabevery 6 months
- lefamulinevery 3 years
- leflunomideevery 3 years
- lenacapavirevery 1 year
- lenalidomideevery 3 years
- leniolisibevery 6 months
- lenograstimevery 5 years
- lenvatinibevery 3 years
- lercanidipineevery 5 years
- leriglitazoneevery 6 months
- lerodalcibepevery 6 months
- letermovirevery 3 years
- letrozoleevery 3 years
- leuprorelin (depot formulations)every 2 years
- levacetylleucineevery 6 months
- levetiracetamevery 3 years
- levobunolol (ophthalmic indication)every 5 years
- levobupivacaineevery 5 years
- levocabastineevery 5 years
- levocetirizineevery 6 years
- levodopaevery 1 year
- levodropropizineevery 7 years
- levofloxacin (Inhalation use)every 5 years
- levofloxacin (intravenous and oral use)every 3 years
- levofloxacin (ocular use)every 5 years
- levofloxacin/dexamethasone (ocular use)every 3 years
- levomentholevery 8 years
- levomepromazineevery 9 years
- levomethadoneevery 5 years
- levonorgestrel (all indications except emergency contraception)every 3 years
- levonorgestrel (for emergency contraception only)every 5 years
- levonorgestrel / ethinylestradiol, ethinylestradiol (combination pack)every 5 years
- levosimendanevery 5 years
- levosulpiride, sulpirideevery 8 years
- levothyroxineevery 5 years
- levothyroxine / potassium iodideevery 9 years
- levothyroxine sodium / liothyronine sodiumevery 9 years
- lidocaine (systemic use)every 8 years
- lidocaine (topical use)every 8 years
- lidocaine / hydrocortisoneevery 10 years
- lidocaine / norepinephrineevery 8 years
- lidocaine / phenazoneevery 5 years
- lidocaine / prilocaine (centrally authorised product only)every 5 years
- lidocaine / prilocaine (not centrally authorised product)every 5 years
- lidocaine / tetracaineevery 8 years
- lidocaine / tribenosideevery 10 years
- lidocaine hydrochloride / methylprednisolone acetateevery 8 years
- lidocaine hydrochloride / neomycin sulfate / polymyxin b, lidocaine hydrochloride monohydrate / fludrocortisone acetate / neomycin sulfate / polymyxin bevery 8 years
- lidocaine hydrochloride / phenylephrine hydrochloride / tropicamideevery 5 years
- linaclotideevery 3 years
- linagliptin, linagliptin / metforminevery 3 years
- lincomycinevery 10 years
- linezolidevery 3 years
- linvoseltamabevery 6 months
- linzagolix cholineevery 1 year
- liothyronineevery 7 years
- lipegfilgrastimevery 3 years
- liquid paraffin / sodium picosulfateevery 13 years
- liraglutide, insulin degludec / liraglutideevery 3 years
- lisdexamfetamineevery 3 years
- lisinopril / torasemideevery 5 years
- lisinopril, lisinopril / hydrochlorothiazideevery 5 years
- lisocabtagene maraleucel / lisocabtagene maraleucelevery 1 year
- lithiumevery 6 years
- lodoxamideevery 8 years
- lofepramineevery 9 years
- lomitapideevery 1 year
- lomustineevery 5 years
- lonafarnibevery 1 year
- lonapegsomatropinevery 3 years
- loncastuximab tesirineevery 6 months
- lonoctocog alfaevery 1 year
- loperamide, loperamide / simeticoneevery 5 years
- lopinavir / ritonavirevery 5 years
- loprazolamevery 9 years
- loratadineevery 5 years
- loratadine / pseudoephedrineevery 5 years
- lorazepamevery 3 years
- lorlatinibevery 1 year
- lormetazepamevery 3 years
- lornoxicamevery 7 years
- losartanevery 8 years
- loteprednolevery 7 years
- lovastatinevery 5 years
- loxapineevery 9 years
- loxapine (pre-dispensed inhalation powder)every 3 years
- lumacaftor / ivacaftorevery 3 years
- lumasiranevery 2 years
- lurasidoneevery 3 years
- lurbinectedinevery 6 months
- luspaterceptevery 1 year
- lusutrombopagevery 3 years
- lutetium (177Lu) chlorideevery 3 years
- lutetium (177Lu) oxodotreotideevery 3 years
- lutetium (177LU) vipivotide tetraxetanevery 1 year
- lutropin alfaevery 5 years
- lymecyclineevery 9 years
- lynestrenolevery 9 years
Source: European Medicines Agency, list of EU reference dates and frequency of submission of periodic safety update reports, EMA/630645/2012 Rev.165, published 21 Oct 2026.