Substances starting with C
Every substance in the newest version of the EU reference dates list that starts with C, with how often a PSUR is due. Open one for its data lock points and submission dates.
367 substances
- C1-inhibitor, human plasma derived (centrally authorised products)every 2 years
- C1-inhibitor, human plasma derived (nationally authorised products)every 2 years
- cabazitaxelevery 5 years
- cabergolineevery 5 years
- cabotegravir (for pre-exposure prophylaxis of HIV-1 infection)every 2 years
- cabotegravir (for treatment of human immunodeficiency virus type 1 (HIV-1)every 2 years
- cabozantinibevery 3 years
- cafedrine hydrochloride / theodrenaline hydrochlorideevery 9 years
- caffeineevery 28 years
- caffeine (apnea)every 3 years
- caffeine / codeine / paracetamolevery 5 years
- caffeine / codeine / paracetamol / propyphenazone, acetylsalicylic acid / caffeine / codeine / paracetamol, acetylsalicylic acid / codeine / paracetamol, buclizine / codeine / paracetamolevery 5 years
- caffeine / dexpanthenol / nicotinamide / pyridoxine / riboflavine / thiaminevery 11 years
- caffeine / dextropropoxyphene / paracetamolevery 8 years
- caffeine / dihydroergocryptine mesilateevery 28 years
- caffeine / dimenhydrinate, dimenhydrinateevery 8 years
- caffeine / diphenhydramineevery 28 years
- caffeine / drotaverine hydrochloride / metamizole sodiumevery 4 years
- caffeine / ergotamineevery 3 years
- caffeine / guaifenesin / paracetamolevery 9 years
- caffeine / isometheptene / metamizoleevery 28 years
- caffeine / metamizoleevery 28 years
- caffeine / moxastine teoclateevery 11 years
- caffeine / paracetamolevery 11 years
- caffeine / paracetamol / phenylephrine hydrochlorideevery 9 years
- caffeine / paracetamol / propyphenazone, paracetamol / propyphenazoneevery 8 years
- caffeine / phenazoneevery 28 years
- caffeine citrate / glyceryl trinitrateevery 28 years
- calcifediolevery 5 years
- calcipotriolevery 8 years
- calcitonin salmon, synthetic analogue of eel calcitoninevery 5 years
- calcitriolevery 5 years
- calciumevery 15 years
- calcium / glucose / glutathione disulphide / magnesium / potassium / sodium / sodium bicarbonateevery 9 years
- calcium bromolactobionateevery 15 years
- calcium carbonateevery 9 years
- calcium carbonate / calcium lactateevery 10 years
- calcium carbonate / famotidine / magnesium hydroxideevery 5 years
- calcium carbonate/ magnesium carbonate/ simeticoneevery 10 years
- calcium chlorideevery 11 years
- calcium chloride / dipotassium phosphate / magnesium chloride hexahydrate / potassium chloride / potassium phosphate monobasic / sodium chloride, disodium phosphate dihydrate/ potassium dihydrogen phosphate/ potassium hydroxideevery 15 years
- calcium chloride / glucose / magnesium chloride / sodium chloride / sodium lactate, calcium chloride / glucose / magnesium chloride / sodium chloride / sodium lactate/ sodium bicarbonate, calcium chloride / amino acids blend / magnesium chloride / sodium chloride / sodium lactate, calcium chloride / icodextrin / magnesium chloride / sodium chloride / sodium lactate (peritoneal dialysis solutions)every 15 years
- calcium chloride / glucose anhydrous / glutathione disulphide / magnesium chloride hexahydrateevery 15 years
- calcium chloride / glucose monohydrate / magnesium chloride hexahydrateevery 15 years
- calcium chloride / glutamic acid / glutathione / histidine / lactobionic acid / magnesium chloride / mannitol / potassium chloride / sodium hydroxideevery 5 years
- calcium chloride / glycine / magnesium aspartate dihydrate / sodium succinate hexahydrateevery 15 years
- calcium chloride / histidine / magnesium chloride / mannitol / potassium chloride / sodium chloride / tryptophan / oxogluric acidevery 6 years
- calcium chloride dihydrate / magnesium chloride hexahydrate / malic acid / sodium acetate trihydrate / sodium chloride / potassium chloride, calcium chloride dihydrate / sodium chloride / sodium lactate / potassium chloride, calcium chloride / sodium chloride / potassium chlorideevery 13 years
- calcium dobesilate / lidocaine, 'calcium dobesilate / dexamethasone / lidocaineevery 10 years
- calcium folinate / cyanocobalaminevery 15 years
- calcium folinate 5-hydrate / glutamineevery 15 years
- calcium gluconateevery 11 years
- calcium gluconate / colecalciferol / nicotinic acidevery 13 years
- calcium glycerophosphate / magnesium gluconate, calcium glycerophosphate / manganese glycerophosphate / potassium glycerophosphate / sodium glycerophosphate / thiamineevery 11 years
- calcium lactateevery 8 years
- calcium levofolinate, calcium folinateevery 15 years
- calcium oxide / ichthammol / potassium aluminium sulfate / sodium perborateevery 9 years
- calcium pantothenateevery 8 years
- calcium thiocyanate / methenamineevery 9 years
- Camellia sinensis, Leaf, Dry extract refined (derived from Camellia sinensis, L. O.KUNTZE) (topical use)every 5 years
- camizestrantevery 6 months
- camphor, camphor and other terpene derivatesevery 9 years
- canagliflozin, canagliflozin / metforminevery 3 years
- canakinumabevery 5 years
- candesartan / indapamideevery 5 years
- candesartan, candesartan / hydrochlorothiazideevery 5 years
- cangrelorevery 3 years
- cannabidiol (for centrally authorised products only)every 3 years
- capecitabineevery 5 years
- capivasertibevery 6 months
- caplacizumabevery 1 year
- capmatinibevery 1 year
- capreomycinevery 9 years
- capsaicinevery 5 years
- captoprilevery 5 years
- captopril / hydrochlorothiazideevery 5 years
- carbacholevery 10 years
- carbaethopendeciniumevery 10 years
- carbaethopendecinium bromide / trimecaine hydrochlorideevery 8 years
- carbamazepineevery 7 years
- carbasalateevery 9 years
- carbasalate calcium / metoclopramide, lysine acetylsalicylic acid / metoclopramide, paracetamol / metoclopramideevery 15 years
- carbazochromeevery 11 years
- carbethopendecinium bromide / salicylic acid / triamcinoloneevery 9 years
- carbetocinevery 5 years
- carbidopa / entacapone / levodopaevery 3 years
- carbidopa / levodopa (only CAP for subcutaneous use)every 6 months
- carbidopa / levodopa, foscarbidopa / foslevodopaevery 3 years
- carbimazoleevery 7 years
- CARBO VEGETABILIS / RESINA PICEAE/ ROBINIA PSEUDOACACIA / STRYCHNOS NUX-VOMICAevery 18 years
- carbocisteineevery 9 years
- carbocisteine / prenoxidiazineevery 9 years
- carbocisteine / promethazine hydrochlorideevery 13 years
- carbomersevery 5 years
- carbon dioxideevery 8 years
- carboplatinevery 5 years
- carboprostevery 5 years
- carfilzomibevery 3 years
- carglumic acidevery 5 years
- cariprazineevery 3 years
- carmellose (eye preparation)every 15 years
- carmustine (implant)every 5 years
- carmustine (powder and solvent for solution for infusion)every 5 years
- carnitine, levocarnitineevery 10 years
- carrageenin / titanium dioxide / zinc oxide, carrageenin / lidocaine / titanium dioxide / zinc oxide, titanium dioxide / zinc oxide / tetracaine hydrochloride, carrageenin / lidocaine / titanium dioxideevery 8 years
- carteololevery 5 years
- carvedilolevery 5 years
- carvedilol / ivabradineevery 3 years
- caspofunginevery 3 years
- catridecacogevery 3 years
- catumaxomabevery 1 year
- cefaclorevery 8 years
- cefadroxilevery 5 years
- cefalexinevery 8 years
- cefalotinevery 10 years
- cefamandoleevery 9 years
- cefatrizineevery 9 years
- cefazolinevery 5 years
- cefditorenevery 8 years
- cefepimeevery 5 years
- cefepime / enmetazobactamevery 3 years
- cefiderocolevery 3 years
- cefiximeevery 5 years
- cefonicidevery 9 years
- cefoperazone, cefoperazone / sulbactamevery 5 years
- cefotaximeevery 3 years
- cefoxitinevery 9 years
- cefpodoximevery 7 years
- cefprozilevery 5 years
- cefradineevery 9 years
- ceftaroline fosamilevery 3 years
- ceftazidimeevery 5 years
- ceftazidime / avibactamevery 5 years
- ceftizoximeevery 9 years
- ceftobiproleevery 3 years
- ceftolozane / tazobactamevery 3 years
- ceftriaxone, ceftriaxone / lidocaineevery 5 years
- cefuroxime axetilevery 5 years
- cefuroxime sodium (except for intracameral use)every 5 years
- cefuroxime sodium (for intracameral use)every 3 years
- celecoxibevery 5 years
- celiprololevery 8 years
- cemiplimabevery 2 years
- cenegerminevery 1 year
- cenobamateevery 1 year
- ceritinibevery 3 years
- cerium nitrate / silver sulfadiazineevery 10 years
- cerliponase alfaevery 3 years
- certolizumabevery 3 years
- certoparinevery 5 years
- cetalkonium / choline salicylate, choline salicylateevery 8 years
- cetirizineevery 5 years
- cetirizine / pseudoephedrineevery 5 years
- cetrimide / chlorhexidineevery 9 years
- cetrimide / lidocaine, cetrimide / lidocaine hydrochloride / zinc sulphateevery 10 years
- cetrimide / quinisocain chlorhydrateevery 8 years
- cetrimide, cetyltrimethylammonium naproxenateevery 15 years
- cetrimonium / chlorhexidineevery 9 years
- cetrimonium bromide / lidocaine / tyrothricinevery 10 years
- cetrorelixevery 5 years
- cetuximabevery 5 years
- cetylpyridinium / lidocaine, lidocaine / chlorocresol / cetylpyridiniumevery 10 years
- cetylpyridinium / lysozyme, lysozyme / pyridoxineevery 10 years
- cetylpyridinium, benzocaine / cetylpyridiniumevery 11 years
- chamomile extract / glucose / potassium chloride / sodium chloride / sodium hydrogen carbonateevery 9 years
- chamomilla vulgaris / phytolacca decandra / rheumevery 18 years
- charcoal activatedevery 28 years
- chenodeoxycholic acid (inborn error in primary bile acid synthesis, xanthomatosis - centrally authorised products only)every 1 year
- chikungunya vaccine (live)every 6 months
- chikungunya vaccine (recombinant, adsorbed)every 6 months
- chloral hydrateevery 9 years
- chlorambucilevery 10 years
- chloramphenicolevery 18 years
- chloramphenicol / cortisone acetate / ethacridine lactate / zinc oxideevery 11 years
- chloramphenicol / dexamethasoneevery 18 years
- chloramphenicol / hydrocortisone (ocular)every 18 years
- chloramphenicol hemisuccinate / prednisolone sodium succinateevery 9 years
- chlordiazepoxideevery 10 years
- chlordiazepoxide / clidinium, amitriptyline / chlordiazepoxideevery 3 years
- chlorhexidineevery 8 years
- chlorhexidine / dexpanthenolevery 9 years
- chlorhexidine / hydrocortisoneevery 8 years
- chlorhexidine / lidocaineevery 10 years
- chlorhexidine / phenolevery 13 years
- chlorhexidine / tetracaineevery 8 years
- chlorhexidine digluconate / lidocaine hydrochloride / tyrothricinevery 13 years
- chlorhexidine gluconate / isopropyl alcohol (covers other synonymous terms such as 2-propanol)every 8 years
- chlormadinoneevery 3 years
- chlormadinone acetate / ethinylestradiolevery 3 years
- chlormethineevery 3 years
- chlorobutanol hemihydrate / choline salicylate / hexetidineevery 9 years
- chlorocresolevery 9 years
- chlorocresol / chlorhexidine / hexamidineevery 7 years
- chloroprocaine hydrochlorideevery 5 years
- chloropyramineevery 8 years
- chloroquineevery 5 years
- chloroxine / triamcinoloneevery 9 years
- chloroxylenolevery 11 years
- chlorphenamineevery 10 years
- chlorphenamine / dextromethorphan hydrobromide / paracetamolevery 10 years
- chlorphenamine / paracetamolevery 7 years
- chlorphenamine / paracetamol / pseudoephedrine, chlorphenamine / paracetamol / phenylephrineevery 10 years
- chlorphenamine / pseudoephedrine, chlorphenamine / phenylephrineevery 10 years
- chlorphenoxamineevery 9 years
- chlorpromazineevery 5 years
- chlorprothixeneevery 3 years
- chlorquinaldolevery 8 years
- chlorquinaldol (vaginal tablet) / promestrieneevery 13 years
- chlortalidoneevery 10 years
- chlortalidone / oxprenololevery 10 years
- chlortalidone / reserpineevery 10 years
- chlortetracyclineevery 11 years
- chlorzoxazoneevery 10 years
- cholera vaccine (inactivated, oral)every 3 years
- cholera vaccine, oral, liveevery 3 years
- cholic acid (oxosteroid-reductase or hydroxy-steroid dehydrogenase deficiency indication)every 3 years
- choline alfoscerateevery 8 years
- choriogonadotropin alfa, chorionic gonadotrophinevery 3 years
- chrome alumevery 9 years
- chromium (51 cr) edtaevery 10 years
- ciclesonideevery 5 years
- ciclopirox and ciclopirox olamineevery 10 years
- ciclosporin (systemic use)every 3 years
- ciclosporin (topical use)every 3 years
- cidofovirevery 3 years
- cilastatin / imipenemevery 5 years
- cilazapril, cilazapril / hydrochlorothiazideevery 5 years
- cilostazolevery 5 years
- ciltacabtagene autoleucelevery 1 year
- cimetidineevery 9 years
- cimicifuga racemosa (L.) nutt., rhizomaevery 5 years
- cinchocaineevery 8 years
- cinchocaine hydrochloride / hydrocortisoneevery 7 years
- cinchocaine hydrochloride / policresulenevery 9 years
- cinchocaine hydrochloride / prednisolone caproate, cinchocaine hydrochloride / fluocortolone caproate / fluocortolone pivalateevery 9 years
- cinitaprideevery 13 years
- cinnarizineevery 10 years
- cinnarizine / dimenhydrinateevery 8 years
- cinnarizine / piracetamevery 9 years
- cinolazepamevery 8 years
- cipaglucosidase alfaevery 1 year
- ciprofibrateevery 5 years
- ciprofloxacin (systemic use)every 5 years
- ciprofloxacin (topical use)every 5 years
- ciprofloxacin / dexamethasone (ear drops, suspension)every 5 years
- ciprofloxacin / fluocinolone acetonideevery 7 years
- ciprofloxacin hydrochloride / hydrocortisoneevery 3 years
- cisatracuriumevery 8 years
- cisplatinevery 5 years
- citalopramevery 5 years
- citicolineevery 10 years
- citric acidevery 28 years
- citric acid / magnesium / sodium, citric acid anhydrous / light magnesium oxide / sodium picosulfateevery 9 years
- citric acid / potassium salts, potassium citrate, potassium sodium hydrogen citrate, citric acid / potassium citrate / sodium citrateevery 6 years
- citric acid / sodiumevery 28 years
- citric acid / ureaevery 28 years
- citrulline malateevery 13 years
- cladribine (apart from products with multiple sclerosis indication)every 3 years
- cladribine (multiple sclerosis)every 3 years
- clarithromycinevery 3 years
- clascoteroneevery 6 months
- clavulanate / ticarcillinevery 10 years
- cleboprideevery 8 years
- clebopride / dimeticoneevery 9 years
- clebopride hydrogen maleate / simeticoneevery 9 years
- clemastineevery 9 years
- clemastine / dexamethasoneevery 7 years
- clenbuterolevery 5 years
- clesrovimabevery 6 months
- clevidipineevery 3 years
- clindamycinevery 3 years
- clindamycin phosphate / tretinoinevery 5 years
- clioquinolevery 9 years
- clioquinol / flumetasoneevery 10 years
- clioquinol / fluocinolone acetonideevery 9 years
- clobazamevery 8 years
- clobetasolevery 5 years
- clobetasoneevery 9 years
- clodronic acid, clodronic acid / lidocaineevery 5 years
- clofarabineevery 3 years
- clofazimineevery 9 years
- clomethiazoleevery 10 years
- clomifeneevery 8 years
- clomipramineevery 8 years
- clonazepamevery 5 years
- clonazoline hydrochloride / fluocinolone acetonideevery 9 years
- clonidineevery 5 years
- clonixinevery 10 years
- clopamide / dihydroegocrystine / reserpineevery 10 years
- cloperastineevery 9 years
- cloprednolevery 9 years
- clorazepateevery 9 years
- clorazepate dipotassiumevery 9 years
- cloricromen hydrochlorideevery 9 years
- clotiapineevery 9 years
- clotiazepamevery 5 years
- clotrimazoleevery 8 years
- clotrimazole / dexamethasoneevery 10 years
- clotrimazole / hexamidine diisetionateevery 9 years
- clotrimazole / hexamidine diisetionate / prednisolone acetateevery 9 years
- clotrimazole / hydrocortisoneevery 10 years
- clotrimazole / metronidazoleevery 7 years
- cloxacillinevery 10 years
- clozapineevery 5 years
- coal tar, distilled coal tar, coconut oil / distilled coal tar / salicylic acid, coal tar solution / salicylic acid / sulfur, coal tar / salicylic acid, coal tar / mentholevery 8 years
- cobamamide, hydroxocobalamin (except for products for chemical poisoning), hydroxocobalamin / cobamamideevery 10 years
- cobicistatevery 3 years
- cobicistat / elvitegravir / emtricitabine / tenofovir alafenamideevery 3 years
- cobicistat / elvitegravir / emtricitabine / tenofovir disoproxilevery 3 years
- cobimetinibevery 3 years
- cod-liver oil (oral and parental use)every 15 years
- cod-liver oil (topical use), cod-liver oil/zinc oxideevery 15 years
- codeineevery 5 years
- codeine / guaifenesin, ammonium chloride / codeine phosphate hemihydrate / guaifenesin / thyme oilevery 7 years
- codeine / ibuprofenevery 5 years
- codeine / paracetamolevery 5 years
- codeine phosphate / diphenhydramine hydrochloride / levomentholevery 9 years
- colchicineevery 5 years
- colecalciferol, colecalciferol / calcium, ergocalciferol, ergocalciferol / calciumevery 5 years
- colesevelamevery 3 years
- colestipolevery 9 years
- colestyramineevery 9 years
- colistimethate sodium (all applications except for dry inhalation powder)every 13 years
- colistimethate sodium (dry inhalation powder)every 3 years
- colistin sulphateevery 10 years
- concentrate of proteolytic enzymes enriched in bromelainevery 2 years
- concizumabevery 1 year
- conestat alfaevery 6 months
- conjugated estrogensevery 10 years
- conjugated estrogens / medrogestoneevery 9 years
- conjugated estrogens / norgestrelevery 9 years
- copper chloride dihydrate / manganese chloride tetrahydrate / potassium iodide / sodium fluoride / sodium selenite anhydrous / zinc chlorideevery 8 years
- corifollitropin alfaevery 3 years
- corticorelinevery 5 years
- cortisoneevery 10 years
- COVID-19 mRNA vaccine (Comirnaty)every 2 years
- COVID-19 mRNA vaccine (mNEXSPIKE)every 1 year
- COVID-19 mRNA vaccine (Spikevax)every 2 years
- COVID-19 sa-mRNA Vaccine (Kostaive)every 1 year
- COVID-19 Vaccine (recombinant, adjuvanted) (Bimervax)every 1 year
- COVID-19 Vaccine (recombinant, adjuvanted) (Nuvaxovid)every 1 year
- crizotinibevery 3 years
- cromoglicic acidevery 5 years
- crotamitonevery 11 years
- crotamiton / hydrocortisoneevery 10 years
- crovalimabevery 6 months
- cyamemazineevery 8 years
- cyanocobalaminevery 10 years
- cyanocobalamin / diclofenac / pyridoxine / thiamineevery 5 years
- cyanocobalamin / folic acid / pyridoxineevery 7 years
- cyanocobalamin / folic acid, cyanocobalamin / folic acid / potassium iodideevery 7 years
- cyanocobalamin / pyridoxine / thiamineevery 10 years
- cyclizineevery 6 years
- cyclobenzaprineevery 12 years
- cyclopenthiazideevery 11 years
- cyclopentolateevery 10 years
- cyclophosphamideevery 12 years
- cycloserineevery 8 years
- cyproheptadineevery 5 years
- cyproteroneevery 5 years
- cyproterone / ethinylestradiolevery 3 years
- cyproterone acetate / estradiol valerateevery 8 years
- cystineevery 11 years
- cystine / pyridoxine hydrochlorideevery 8 years
- cytarabineevery 5 years
- cytisine, cytisiniclineevery 13 years
- cytomegalovirus immunoglobulinevery 5 years
Source: European Medicines Agency, list of EU reference dates and frequency of submission of periodic safety update reports, EMA/630645/2012 Rev.165, published 21 Oct 2026.