Substances starting with S
Every substance in the newest version of the EU reference dates list that starts with S, with how often a PSUR is due. Open one for its data lock points and submission dates.
157 substances
- saccharomyces boulardiievery 5 years
- sacituzumab govitecanevery 3 years
- sacubitril / valsartanevery 2 years
- safinamideevery 5 years
- salbutamolevery 3 years
- salicylamideevery 8 years
- salicylic acid (ocular use)every 6 years
- salicylic acid (topical use)every 6 years
- salicylic acid / triamcinolone acetonideevery 8 years
- salmeterolevery 5 years
- salmeterol / fluticasone propionate (for centrally authorised products)every 3 years
- samarium (153sm) lexidronamevery 5 years
- sapropterinevery 3 years
- sargramostimevery 6 months
- sarilumabevery 3 years
- satralizumab (for centrally authorised products)every 1 year
- saxagliptin, metformin / saxagliptinevery 3 years
- scopolamine aminoxide hydrobromideevery 9 years
- sebelipase alfaevery 3 years
- sebetralstatevery 6 months
- secale cereale L., phleum pratense, zea mays L. single or mixes (genitourinary therapy)every 5 years
- secnidazoleevery 9 years
- secukinumabevery 3 years
- seladelpar lysine dihydrateevery 6 months
- selegilineevery 8 years
- seleniumevery 8 years
- selexipagevery 3 years
- selinexorevery 3 years
- selpercatinibevery 6 months
- selumetinibevery 6 months
- semaglutide (all other indications)every 2 years
- semaglutide (treatment of adults with non-cirrhotic metabolic dysfunction-associated steatohepatitis with liver fibrosis)every 6 months
- sepiapterinevery 6 months
- serenoa repensevery 5 years
- serplulimabevery 6 months
- serrapeptaseevery 10 years
- sertaconazoleevery 10 years
- sertindoleevery 5 years
- sertralineevery 5 years
- setmelanotideevery 1 year
- sevelamerevery 3 years
- sevofluraneevery 5 years
- shark liver oil / yeast extract, yeast extract (excluding saccharomyces boulardii)every 15 years
- sildenafil (indicated for erectile dysfunction)every 5 years
- sildenafil (indicated for pulmonary hypertension)every 3 years
- silibinin, dry extract from Milk Thistle fruit (silymarin))every 9 years
- silodosinevery 3 years
- siltuximabevery 3 years
- silver nitrateevery 8 years
- silver sulfadiazineevery 8 years
- simeticone, pancreatin / simeticone, dimethicone / pancreatin, pancreatic enzymes, pancreatic extracts, pancreatinevery 9 years
- simoctocog alfaevery 2 years
- simvastatinevery 5 years
- sipavibartevery 1 year
- siponimodevery 3 years
- sirolimus (for prophylaxis of organ rejection indication)every 3 years
- sirolimus (indicated for treatment of angiofibroma associated with tuberous sclerosis complex)every 1 year
- sitagliptin, metformin / sitagliptinevery 3 years
- smallpox and monkeypox vaccine (Live Modified Vaccinia Virus Ankara)every 1 year
- sobrerolevery 9 years
- sodium acetateevery 20 years
- sodium benzoate / sodium phenylacetateevery 9 years
- sodium bicarbonate / sodium hydrogen phoshate / sodium sulphateevery 11 years
- sodium chlorideevery 10 years
- sodium chloride (eye drops)every 9 years
- sodium chloride (nasal drops)every 9 years
- sodium chloride / ureaevery 8 years
- sodium citrate (extracorporeal use)every 8 years
- sodium citrate / sodium lauryl sulfoacetate, sodium citrate / sodium lauryl sulfoacetate / sorbitolevery 7 years
- sodium feredetateevery 8 years
- sodium fluoride (18F)every 5 years
- sodium fluoride, colecalciferol / sodium fluoride, dectaflur / olaflur / sodium fluorideevery 9 years
- sodium glycerophosphate pentahydrateevery 8 years
- sodium hyaluronate / sulfadiazine silverevery 8 years
- sodium hydrogen carbonateevery 9 years
- sodium hypochlorite (concentrated solution)every 8 years
- sodium iodide (123i)every 7 years
- sodium iodide (131i)every 5 years
- sodium iron gluconate (parenteral use)every 3 years
- sodium nitroprussideevery 9 years
- sodium oleateevery 13 years
- sodium oxybate (intravenous use)every 5 years
- sodium oxybate (oral use)every 1 year
- sodium phenylbutyrateevery 3 years
- sodium picosulfateevery 9 years
- sodium pyrophosphate, technetium (99mtc) pyrophosphate (for diagnosistic purpose)every 15 years
- sodium tetradecyl sulphateevery 3 years
- sodium thiosulfateevery 2 years
- sodium thiosulfate (except centrally authorised products)every 10 years
- sodium zirconium cyclosilicateevery 3 years
- sofosbuvirevery 5 years
- sofosbuvir / ledipasvirevery 5 years
- sofosbuvir / velpatasvirevery 5 years
- sofosbuvir / velpatasvir / voxilaprevirevery 5 years
- solifenacinevery 5 years
- solifenacin / tamsulosinevery 5 years
- solriamfetolevery 3 years
- solutions for haemofiltration and haemodiafiltration, solutions for haemodialysisevery 9 years
- somapacitanevery 3 years
- somatorelinevery 9 years
- somatostatinevery 8 years
- somatrogonevery 3 years
- somatropinevery 3 years
- sonidegibevery 2 years
- sorafenibevery 5 years
- sorbitolevery 8 years
- sotalolevery 7 years
- sotaterceptevery 1 year
- sotorasibevery 6 months
- soybean phospholipids (oral use)every 5 years
- spaglumic acidevery 9 years
- sparsentanevery 1 year
- spectinomycinevery 10 years
- spesolimabevery 6 months
- spheroids of human autologous matrix-associated chondrocytesevery 3 years
- spiramycinevery 9 years
- spironolactoneevery 3 years
- standardised bacterial culture suspension, standardised bacterial culture suspension / hydrocortisone, inactivated E. coli, inactivated E. coli / hydrocortisoneevery 15 years
- sterculia, frangula / sterculiaevery 10 years
- stibogluconateevery 10 years
- stiripentolevery 1 year
- streptodornase / streptokinaseevery 11 years
- streptokinaseevery 10 years
- streptomycinevery 10 years
- streptozocinevery 9 years
- strontium chloride hexahydrateevery 9 years
- succinylated gelatin, sodium chloride / sodium hydroxide / succinylated gelatin, calcium chloride / magnesium chloride / potassium chloride / sodium acetate /sodium chloride / succinylated gelatin, gelatin / sodium chloride / potassium chloride / magnesium chloride hexahydrate / sodium lactateevery 15 years
- sucralfateevery 9 years
- sucroferric oxyhydroxideevery 3 years
- sucroseevery 8 years
- sufentanilevery 3 years
- sugammadexevery 5 years
- sugemalimabevery 6 months
- sulbutiamineevery 10 years
- sulconazoleevery 9 years
- sulfacetamideevery 10 years
- sulfadiazineevery 8 years
- sulfaguanidineevery 10 years
- sulfamethizoleevery 10 years
- sulfametrole / trimethoprim, sulfadiazine / trimethoprim, sulfamethoxazole / trimethoprim (co-trimoxazole)every 8 years
- sulfasalazineevery 10 years
- sulfinpyrazoneevery 10 years
- sulfogaiacol, sodium benzoate / sulfogaiacol, codeine / sodium benzoate, codeine sulfogaiacol, codeine / sulfogaiacol / grindelia soft extractevery 5 years
- sulfur hexafluorideevery 3 years
- sulindacevery 9 years
- sulodexideevery 10 years
- sulprostoneevery 3 years
- sultamicillinevery 5 years
- sultiameevery 10 years
- sultoprideevery 9 years
- sumatriptan, naproxen / sumatriptanevery 5 years
- sunitinibevery 3 years
- susoctocog alfaevery 3 years
- sutimlimabevery 1 year
- suxamethoniumevery 3 years
- suxibuzoneevery 10 years
- Symphytum officinale L., radix (comfrey root)every 13 years
Source: European Medicines Agency, list of EU reference dates and frequency of submission of periodic safety update reports, EMA/630645/2012 Rev.165, published 21 Oct 2026.