Substances starting with A
Every substance in the newest version of the EU reference dates list that starts with A, with how often a PSUR is due. Open one for its data lock points and submission dates.
291 substances
- a-tocopheril, a-tocopherol, vitamin Eevery 8 years
- a-tocopherol / ergocalciferol / phytomenadion / retinol palmitateevery 10 years
- a-tocopherol nicotinate / retinol palmitateevery 11 years
- abacavirevery 3 years
- abacavir / lamivudineevery 3 years
- abacavir / lamivudine / zidovudineevery 3 years
- abaloparatideevery 1 year
- abataceptevery 3 years
- abemaciclibevery 3 years
- abirateroneevery 5 years
- abrocitinibevery 1 year
- acalabrutinibevery 1 year
- acamprosateevery 8 years
- acarboseevery 5 years
- acebutololevery 8 years
- aceclofenacevery 5 years
- acemetacinevery 6 years
- acenocoumarolevery 3 years
- acetazolamideevery 16 years
- acetylated wool alcohols / liquid paraffinevery 9 years
- acetylcholineevery 16 years
- acetylcysteineevery 5 years
- acetylcysteine / tuaminoheptane, acetylcysteine / benzalkonium chloride / tuaminoheptaneevery 9 years
- acetylsalicylic acidevery 8 years
- acetylsalicylic acid / ascorbic acid / bioflavonoidsevery 23 years
- acetylsalicylic acid / ascorbic acid / codeine phosphate hemihydrateevery 23 years
- acetylsalicylic acid / ascorbic acid / paracetamol, acetylsalicylic acid / paracetamolevery 15 years
- acetylsalicylic acid / ascorbic acid, acetylsalicylic acid / citric acid / sodium hydrogen carbonateevery 23 years
- acetylsalicylic acid / atorvastatin / ramiprilevery 3 years
- acetylsalicylic acid / bisoprololevery 7 years
- acetylsalicylic acid / caffeineevery 18 years
- acetylsalicylic acid / caffeine / codeine phosphateevery 18 years
- acetylsalicylic acid / caffeine / etenzamideevery 18 years
- acetylsalicylic acid / caffeine / paracetamolevery 15 years
- acetylsalicylic acid / chlorphenamine / phenylephrineevery 8 years
- acetylsalicylic acid / clopidogrel, clopidogrelevery 3 years
- acetylsalicylic acid / codeine phosphateevery 18 years
- acetylsalicylic acid / glycineevery 18 years
- acetylsalicylic acid / oxycodone hydrochlorideevery 9 years
- acetylsalicylic acid/rosuvastatinevery 5 years
- aciclovirevery 3 years
- aciclovir / hydrocortisoneevery 5 years
- acipimoxevery 5 years
- acitretinevery 2 years
- aclidinium bromideevery 1 year
- aclidinium bromide / formoterol fumarate dihydrateevery 3 years
- acoramidisevery 6 months
- acrivastine, acrivastine / pseudoephedrineevery 7 years
- activated attapulgite mormoiron, activated attapulgite / aluminium / pectinevery 10 years
- adagrasibevery 6 months
- adalimumabevery 3 years
- adapaleneevery 8 years
- adapalene / benzoyl peroxideevery 3 years
- ademetionineevery 8 years
- adenosineevery 5 years
- afamelanotideevery 2 years
- afatinibevery 5 years
- aficamtenevery 6 months
- aflibercept (oncological indication(s))every 5 years
- aflibercept (ophthalmological indication(s))every 3 years
- agalsidase alfaevery 3 years
- agalsidase betaevery 3 years
- agomelatineevery 5 years
- ajmalineevery 10 years
- albendazoleevery 5 years
- albumin tannate / ethacridine lactate monohydrateevery 9 years
- albutrepenonacog alfaevery 3 years
- alclometasoneevery 18 years
- aldesleukinevery 7 years
- alectinibevery 3 years
- alemtuzumabevery 3 years
- alendronateevery 5 years
- alendronic acid / colecalciferol, alendronic acid / calcium / colecalciferolevery 5 years
- alfa amylaseevery 10 years
- alfa-tocopherol / vaccinium myrtillus anthocyanosides, betacarotene / vaccinium myrtillus anthocyanosidesevery 9 years
- alfacalcidolevery 7 years
- alfatocopherol / ascorbic acid / biotin / calcium pantothenate / colecalciferol / cyanocobalamin / magnesium / manganese / pyridoxine / riboflavin / thiamine / vitamin a / zincevery 23 years
- alfatocopherol acetate / ascorbic acid / ergocalciferol / retinolevery 23 years
- alfentanilevery 3 years
- alfuzosinevery 5 years
- alglucosidase alfaevery 3 years
- alimemazineevery 18 years
- alirocumabevery 3 years
- aliskiren, aliskiren / hydrochlorothiazideevery 3 years
- alitretinoin (oral use)every 1 year
- alizaprideevery 5 years
- allantoinevery 18 years
- allantoin / dexpanthenol / diphenhydramine hydrochlorideevery 9 years
- allantoine / povidone iodinatedevery 9 years
- allergen for diagnostic and/or therapy: Apis mellifera (801) (with or without adjuvant), Apis mellifera venomevery 5 years
- allergen for diagnostic and/or therapy: Vespula SPP. (802) (with or without adjuvant), Wasp venomevery 5 years
- allergen for diagnostic: grass pollen, tree pollen, house dust mites, moulds, weed pollen, vertebrates, animal epithelia (except for hymenoptera venoms) single or mixes, positive and negative controlsevery 10 years
- allergen for therapy: Ambrosia Artemisiifolia (302) (sublingual use, products authorised via decentralised procedure)”every 3 years
- allergen for therapy: betula verrucosa (sublingual use)every 3 years
- allergen for therapy: Dactylis Glomerata L., Phleum Pratense L., Anthoxanthum Odoratum L., Lolium Perenne L., Poa Pratensis L. (sublingual tablet)every 3 years
- allergen for therapy: Dactylis Glomerata L., Phleum Pratense L., Anthoxanthum Odoratum L., Lolium Perenne L., Poa Pratensis L. Salsola Kali L., Blomia Tropicalis, Zea Mays L., Fraxinus Excelsior L., Arrhenatherum Elatius, Cynodon Dactylon (L.) pers., latex, Festuca Pratensis Hudson, Parietaria Officinalis L., Cat Epithelia, Dog Epithelia, Triticum Aestivum, Dermatophagoides Farinae, Juniperus Ashei Buchholz, Hordeum Vulgare L., Alnus Glutinosa L., Agrostis Capillaris L., Corylus Avellana L., Secale Cereale L., Avena Fatua whole., Holcus Lanatus, Artemisia Vulgaris L., Olea Europaea L., Ambrosia Artemisiifolia, Dermatophagoides Pteronyssinus, Carpinus Betulus L., Avena Sativa L., Bromus Inermis whole, Parietaria Judaica L., Betula single or mixes (Staloral)every 8 years
- allergen for therapy: dermatophagoides pteronyssinus / dermatophagoides farina (oromucosal use, products authorised via mutually recognition procedure and decentralised procedure)every 3 years
- allergen for therapy: Phleum Pratense (oromucosal use, product authorised via mutually recognition procedure)every 5 years
- allergen products for treatment: grass pollen, tree pollen, house dust mites, moulds, weed pollen, vertebrates, animal epithelia (except for hymenoptera venoms) single or mixes (subcutaneous use)every 8 years
- allopurinolevery 3 years
- alminoprofenevery 10 years
- almotriptanevery 5 years
- alogliptin, alogliptin / metformin, alogliptin / pioglitazoneevery 3 years
- alpelisib (Piqray)every 3 years
- alpelisib (Vijoice)every 6 months
- alprazolamevery 5 years
- alprostadil (erectile dysfunction)every 5 years
- alprostadil (indicated in peripheral arterial occlusive diseases)every 8 years
- alprostadil (patency of the ductus arteriosus)every 3 years
- alteplaseevery 5 years
- altizide / spironolactoneevery 3 years
- aluminiumevery 9 years
- aluminium chlorhydroxide-complexevery 10 years
- aluminium chloride hexahydrateevery 10 years
- aluminium hydroxide gel / dimeticone / magnesium hydroxideevery 9 years
- aluminium oxide / magnesium hydroxide / simeticoneevery 9 years
- aluminium oxide hydrated / magnesium hydroxide / monmectiteevery 9 years
- alverine, alverine / simeticoneevery 10 years
- amantadineevery 6 years
- ambazoneevery 7 years
- ambenoniumevery 11 years
- ambrisentanevery 3 years
- ambroxolevery 5 years
- ambroxol / clenbuterolevery 5 years
- amcinonideevery 10 years
- amfepramoneevery 13 years
- amidotrizoic acid and combinationevery 11 years
- amifampridineevery 3 years
- amikacin (centrally authorised product only)every 1 year
- amikacin (except for centrally authorised products)every 5 years
- amiloride, amiloride / furosemide, amiloride / hydrochlorothiazide, amiloride / hydrochlorothiazide / timolol, amiloride / bumetanide, amiloride / chlortalidoneevery 8 years
- aminaphtoneevery 13 years
- amino acid combinations (only combinations of pure amino acids or combination of amino acids with mineral compounds / electrolytes, oral use)every 7 years
- amino acid combinations (only combinations of pure amino acids or combination of amino acids with mineral compounds/electrolytes, i.v. application)every 7 years
- amino acid combinations / glucose / triglyceride combinations (e.g. olive oil, soya bean oil, fish oil)/ with or without electrolytes/ mineral compounds (i.v. application) - except the combination with procedure number 00010190 (drug Numeta)every 5 years
- amino acid combinations / glucose / triglyceride combinations (e.g. olive oil, soya bean oil, fish oil)/ with or without electrolytes/ mineral compounds (i.v. application) - only for the drug Numetaevery 3 years
- amino acid combinations/ glucose/ with or without electrolytes / mineral compounds (i.v. application)every 5 years
- aminoacids / chloramphenicol / vitamin aevery 18 years
- aminoacridine / lidocaineevery 12 years
- aminocaproic acidevery 9 years
- aminomethylbenzoic acidevery 10 years
- aminophyllineevery 7 years
- amiodaroneevery 3 years
- amisulprideevery 3 years
- amitriptyline / perphenazineevery 3 years
- amitriptyline, amitriptyline / amitriptylinoxide, amitriptylinoxideevery 3 years
- amivantamabevery 1 year
- amlodipineevery 5 years
- amlodipine / atorvastatinevery 5 years
- amlodipine / atorvastatin / perindopril, amlodipine / atorvastatin / ramiprilevery 5 years
- amlodipine / bisoprolol, amlodipine / nebivololevery 9 years
- amlodipine / candesartan, amlodipine / candesartan / hydrochlorothiazide, candesartan / amlodipine / atorvastatinevery 5 years
- amlodipine / indapamide, amlodipine / indapamide / perindoprilevery 5 years
- amlodipine / lisinoprilevery 5 years
- amlodipine / losartanevery 5 years
- amlodipine / olmesartanevery 5 years
- amlodipine / perindoprilevery 5 years
- amlodipine / ramipril, amlodipine / hydrochlorothiazide / ramipril, hydrochlorothiazide / ramiprilevery 3 years
- amlodipine / rosuvastatin, amlodipine / perindopril / rosuvastatin, rosuvastatin / perindopril / indapamide, rosuvastatin / perindopril, rosuvastatin / ramiprilevery 5 years
- amlodipine / telmisartan, amlodipine / telmisartan / hydrochlorothiazideevery 5 years
- amlodipine / valsartan, amlodipine / hydrochlorothiazide / valsartanevery 5 years
- amlodipine besilate / hydrochlorothiazide / olmesartan medoxomilevery 5 years
- amlodipine/irbesartanevery 5 years
- ammonia solutionsevery 16 years
- ammonium chloride / diphenhydramine hydrochloride / sodium citrateevery 9 years
- ammonium chloride, ammonium chloride combinationsevery 16 years
- amorolfineevery 5 years
- amoxapineevery 9 years
- amoxicillinevery 5 years
- amoxicillin / clarithromycin / omeprazoleevery 9 years
- amoxicillin / clarithromycin / pantoprazoleevery 3 years
- amoxicillin / clavulanateevery 5 years
- amoxicillin / lansoprazole / metronidazoleevery 9 years
- amphotericin bevery 15 years
- amphotericin b / tetracyclineevery 11 years
- ampicillinevery 9 years
- ampicillin / cloxacillinevery 10 years
- ampicillin / sulbactamevery 3 years
- amsacrineevery 5 years
- amylase / bromelain / chymotrypsin / lipase / pancreatin / papain / rutoside / trypsin, trypsin/ bromelain/ rutoside trihydrateevery 9 years
- amylase / cortex granati / gentiana lutea / lipase / quercus cortex / radix ratanhiae / rhizoma tormentillae / salicylic acid / tannic acid / trypsinevery 9 years
- amylmetacresol / dichlorobenzyl alcohol / levomentholevery 18 years
- amylmetacresol / dichlorobenzyl alcohol / lidocaineevery 18 years
- amylmetacresol / dichlorobenzyl alcohol, amylmetacresol / ascorbic acid / dichlorobenzyl alcoholevery 9 years
- anagrelideevery 5 years
- anakinraevery 5 years
- anamirta cocculus / strychnos nux-vomica / petroleum / nicotiana tabacumevery 18 years
- anastrozoleevery 3 years
- andexanet alfaevery 6 months
- anethole trithioneevery 28 years
- angiotensin IIevery 3 years
- anhydrous caffeine / codeine phosphate / diphenhydramine hydrochloride / paracetamol, caffeine / codeine phosphate / diphenhydramine hydrochloride / paracetamol / phenylephrine hydrochloride / ascorbic acid, caffeine / codeine phosphate / diphenhydramine hydrochloride / paracetamol / phenylephrine hydrochlorideevery 9 years
- anidulafunginevery 5 years
- anifrolumabevery 1 year
- aniracetamevery 10 years
- antazolineevery 23 years
- antazoline / naphazolineevery 11 years
- antazoline / tetryzolineevery 10 years
- antazoline / xylometazolineevery 11 years
- anthrax vaccineevery 3 years
- anti-t lymphocyte immunoglobulin for human use, rabbitevery 3 years
- antithrombin IIIevery 5 years
- Any combinations of alginate sodium, alginic acid (antacids)every 7 years
- Any combinations or monocomponents of aluminium, calcium, magnesium, potassium, sodium salts (antacids)every 15 years
- apalutamideevery 3 years
- apixabanevery 3 years
- apomorphineevery 5 years
- apraclonidineevery 10 years
- apremilastevery 3 years
- aprepitantevery 5 years
- aprocitentanevery 1 year
- aprotininevery 2 years
- aprotinin / calcium chloride / human factor xiii / human fibrinogen / human thrombin, aprotinin / fibrinogen / fibronectin / human coagulation factor XIII / plasma protein fraction / plasminogen / thrombin, aprotinin / human fibrinogen / thrombin / calcium chloride, aprotinin / calcium chloride / factor xiii / human thrombin / human clottable protein containing mainly fibrinogen and fibronectin, calcium chloride / human fibrinogen / factor xiii / fibronectin / plasminogen / human thrombin / bovine aprotinin, calcium chloride / human fibrinogen / factor xiii / fibronectin / human thrombin / bovine aprotinin, human fibrinogen / calcium chloride dihydrate / plasma fibronectin / thrombin / bovine aprotinin / human coagulation factor xiii, human fibrinogen / calcium chloride dihydrate / plasma protein fraction / fibronectin / thrombin / bovine aprotinin / human coagulation factor xiii, human fibrinogen / plasminogen / human thrombin / bovine aprotinin / human coagulation factor xiii / human fibronectinevery 5 years
- argatrobanevery 2 years
- arginine aspartateevery 10 years
- arginine hydrochloride / cyanocobalamin / cyproheptadine hydrochloride / levocarnitineevery 9 years
- argipressinevery 3 years
- aripiprazoleevery 3 years
- arnica montana / arum triphyllum / belladonna, bromum / bryonia / mercurius solubilis / phytolacca decandra / pulsatilla / spongia testaevery 18 years
- arsenic trioxideevery 5 years
- artemether / lumefantrin (apart from the dispersible tablet)every 3 years
- artenimol / piperaquine tetraphosphateevery 5 years
- artesunateevery 2 years
- articaineevery 20 years
- articaine / epinephrineevery 20 years
- asciminibevery 1 year
- ascorbic acid / acid folic / alfa-tocopherol / biotin / cholecalciferol / cyanocobalamin / nicotinamide / pantothenic acid / pyridoxine hydrochloride / retinol / riboflavin / thiamineevery 8 years
- ascorbic acid / biotin / calcium pantotenateevery 9 years
- ascorbic acid / caffeine / chlorphenamine / paracetamolevery 10 years
- ascorbic acid / caffeine / glucuronamideevery 23 years
- ascorbic acid / caffeine / paracetamolevery 23 years
- ascorbic acid / caffeine / paracetamol / phenylephrine hydrochloride / terpineevery 8 years
- ascorbic acid / calcium, ascorbic acid / calcium / lysineevery 9 years
- ascorbic acid / chlorphenamine / paracetamolevery 6 years
- ascorbic acid / colecalciferol / retinolevery 9 years
- ascorbic acid / dichlorobenzyl alcoholevery 23 years
- ascorbic acid / guaifenesin / paracetamol / phenylephrine hydrochlorideevery 9 years
- ascorbic acid / magnesium aspartate / leucine L / lysine L / phenylalanine L / valine Levery 10 years
- ascorbic acid / magnesium oxide, magnesium oxideevery 7 years
- ascorbic acid / paracetamolevery 23 years
- ascorbic acid / paracetamol / phenylephrine hydrochlorideevery 5 years
- ascorbic acid / paracetamol / propyphenazoneevery 11 years
- ascorbic acid / paracetamol / pseudoephedrineevery 9 years
- ascorbic acid / potassium aspartate / potassium bicarbonateevery 28 years
- ascorbic acid / rutoside, ascorbic acid / rutoside / alfatocopherolevery 8 years
- ascorbic acid, ascorbic acid / sodium ascorbateevery 11 years
- asenapineevery 5 years
- asfotase alfaevery 3 years
- asparaginase (centrally authorised product)every 3 years
- asparaginase, crisantaspase (L-asparaginase from Erwinia chrysanthemi)every 3 years
- aspergillus orizae / pancreatinevery 9 years
- atazanavirevery 5 years
- atazanavir / cobicistatevery 5 years
- atenololevery 12 years
- atenolol / chlortalidoneevery 7 years
- atezolizumabevery 2 years
- atidarsagene autotemcelevery 3 years
- atogepantevery 6 months
- atomoxetineevery 5 years
- atorvastatinevery 6 years
- atorvastatin / ezetimibeevery 7 years
- atosibanevery 5 years
- atovaquoneevery 13 years
- atovaquone / proguanilevery 5 years
- atracuriumevery 10 years
- ATROPA BELLA-DONNA / VIBURNUM OPULUS / CHELIDONIUM MAJUS / ACONITUM NAPELLUS / CALENDULA OFFICINALIS / ABRUS PRECATORIUSevery 18 years
- atropine (except myopia indication)every 14 years
- atropine (myopia indication)every 1 year
- atropine / diphenoxylateevery 14 years
- atropine sulfate / phenylephrine acetate / prednisolone acetateevery 11 years
- autologous CD34+ enriched cell fraction that contains CD34+ cells transduced with retroviral vector that encodes for the human ADA cDNA sequenceevery 3 years
- avacopanevery 1 year
- avalglucosidase alfaevery 3 years
- avanafilevery 5 years
- avapritinibevery 6 months
- avatrombopagevery 3 years
- avelumabevery 3 years
- aviptadil / phentolamine mesilateevery 5 years
- axicabtagene ciloleucelevery 1 year
- axitinibevery 3 years
- azacitidineevery 5 years
- azathioprineevery 6 years
- azelaic acidevery 8 years
- azelastineevery 3 years
- azelastine / fluticasoneevery 5 years
- azilsartan medoxomil, azilsartan medoxomil/chlortalidoneevery 3 years
- azithromycin (ocular use formulations)every 5 years
- azithromycin (systemic use formulations)every 3 years
- aztreonam (inhalation use)every 5 years
- aztreonam (parenteral use)every 7 years
- aztreonam / avibactamevery 6 months
Source: European Medicines Agency, list of EU reference dates and frequency of submission of periodic safety update reports, EMA/630645/2012 Rev.165, published 21 Oct 2026.